the only workaround i found was the pidgin skype-web plugin, which can be a little buggy, but it's far preferable if all you use skype for is IM.
I used to work on a virtualised Windows machine (work mandated) and the only usable accessibility option was a high DPI setting. The old Lync client worked perfectly with this, obviously dating back to an age where they cared about accessibility. Skype for business completely ignored system DPI settings, made certain things huge with other things being tiny.
The spacing was the biggest issue - literally 30-40% of my 43" monitor would often be taken up by spacing around icons etc on the app.
It really felt as though they just stopped putting as much effort into UX, accessibility, usability. Lync felt like a professional IM client, Skype for Business felt like a half baked bodge.