Looks like I placed too much weight on your parenthetical "and themselves"

> interactions between cell types and their environment (and themselves) is a giant information content multiplier

and we're actually in agreement; my first comment included:

> I'm not so sure about the simulation

> The only other source of information is the non-genomic environment - extra-nucleur DNA like mitochondria, and the womb (which is arguably already specified in the genome, unless mother nature has done a Ken Thompson http://cm.bell-labs.com/who/ken/trust.html at some point.)