Yes. In a previous life I lived in an area that's mostly a spread out suburb. I got so depressed that I couldn't walk anywhere, I mean, absolutely nowhere. I felt pretty housebound during the summer and yet I felt at the same time there wasn't really any place to go. Jumping in the car every time I needed to leave the house was just not relaxing!

Now I live in a small town and boy do I love it! Since it's a small town there's not really any huge roads and very little traffic. The streets beyond the major thru fares are quiet and the neighbors are friendly. If I'm bored and feeling restless I can walk to the park (half mile, maybe), the local watering hole (2 blocks), the coffee shop (1 block), or even the convenience store (about a quarter mile). I mean, just getting up and taking a short walk to the convenience store seems to be really beneficial to my mental health for some reason, yet driving there does the opposite.

And transit can't really pick up the slack since there is no core target that large numbers of people want to reach. Successful transit can take a dispersed residential population to a central core or a centralized population to dispersed employment zones but not both.