That being said, I actually did install MS-DOS 6.22 on three computers over the last couple of years, because the company I work at does - among other things - industrial automation, and (at least) one of our customers has a plant built with automation technology that can apparently only be programmed and configured with a program running on DOS. And it must do some rather funky things, because the software will reliably fail to talk to the PLC if it is running in a virtual machine or on FreeDOS. And of course the company that has written this software has gone out of business a long time ago, so there won't be any updates, either. ;-) If I didn't have more important things to do, figuring out why it does not work on FreeDOS could have been a lot of fun, but just installing MS DOS was the faster solution.
Still, installing DOS these days is an interesting experience. The whole system comes on three floppy disks, the installation procedure takes about 15 minutes, and the freshly installed system boots up in about 30 seconds, including the BIOS doing its thing. Admittedly, you cannot do very much with it without additional software.
Three floppy disks - that is about 4.5 Megabyte, Ladies and Gentlemen. Today's high end CPUs have as much L2 cache, or more.
And primitive as it is, there are situations where DOS is a reasonable choice.
I'm still glad, though, that I never had to deal with segmented memory. That sounds horrible.