When I was a kid and lived in Santa Cruz, we would always have to drive to SFO for international flights because SJC's runway was too short for some of the bigger jumbos. Now with 350s and 787s, its not an issue.
Slot utilization at busy airports is one of the better pro-jumbo arguments going around at the moment, though. There's just not enough market pressure to cause airlines to push passengers away from direct flights and towards less popular routing options right now.
I think perhaps using London as an example is overshadowing the point being made. If you aren't aggregating passengers at hubs which you then use larger planes for the common leg of the journey, you don't need as many larger planes.
Also, it's totally possible that there's a better example of a rote enabled by the 787 than New Orleans/London. That's just one that came to mind.
[1] - https://www.forbes.com/sites/marcbabej/2014/12/11/airbus-a38...
[2] - https://centreforaviation.com/insights/analysis/787-network-... (though you only get a lame summary of the article without an account)