Things that are a deal breaker for me:
Template language... You can call it 'separation of concerns' all you want, but just let me generate templates using the language I already know, JSX is great
State management... I cut my teeth with Ember professionally for a few years, and really loved it up until I built a data intensive app. Having state spread across different controllers is great when you have many different routes and pages, but if one page turns in to a photoshop like app, controllers make a terrible state management tool. It doesn't seem overly complicated to me to use redux along with react-redux's connect function to connect regular functions returning JSX to your state object. Looking at Vue.js, it seems like I need to learn Ember-lite + Angular (custom directives).