I'm not claiming that one can't be successful by using Python (or pretty much any programming language). Market success or user count are unfortunately not tightly correlated with technical excellence, as many of us have bitterly found out.
Development speed, maintainability, error count are also important development issues. Unfortunately we don't have much data to judge, but the little that we have such as this article indicate that dynamic typing has a non-negligible negative impact on the above.
""having to push the performance of your product is a nice problem to have and you will probably have the money to spend solving it by either optimising your python or rewriting parts of your application, as all these large companies have done.""
Not considering the topic at all is negligent. I don't understand why you're so sure that the only possible outcomes are either not reaching scale or having the money to optimise or rewrite.
First of all, not even Facebook had the money to rewrite their PHP code base, so that's probably out of the question.
And it's very well possible that one will reach scale and not have the money (or worse the time) to optimise, if optimising means inventing type checkers.
At least one should spend some time thinking about this topic and picking a language that is flexible and can scale at least somewhat. Having to stop writing production code in order to invent a Ruby static type checker or native compiler is decidedly not a good problem to have.