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So does donating blood on a regular basis reduce vaccine efficacy over time? It seems you'd be giving away the T-cells. For a person with 8 pints of blood, making 5 one pint donations would reduce the number of original T-cells by about half. Unless there is a storage place for them. Do these have an affinity for hanging out in the spleen compared to other cells? That would prevent their loss during bleeding.

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From what I remember, T-cells (or was it B cells?) hang out in the lymph nodes.

Yes, the spleen is one location for lymphocytes to hang out, as well as lymph nodes and other locations. Memory B cells will retain their immunologic memory so you can quickly create the antibodies for pathogens after vaccination. I doubt vaccine efficacy would change much as a result.

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