These really are completely different type of computers - I believe if you can apply the MSP430 successfully to your application then the GA144 is probably the wrong chip to use.
But what if you need real-time nano-second reaction times on many separate pins? What if you need to process a 30 Mhz signal? While controlling a display and accepting input? All at the same time?
Then you might need the GA144, which can do all those things at the same time without needing to worry about interrupts or waking up from low power sleep modes or any of the other complex mechanism computers employ to minimize power loss.