Long time NoScript user here, and I had to remove it today as it is completely broken and unusable. I cannot even get the preferences to open so I can export my whitelisted domains to uMatrix, which I'm testing as a replacement.
I would like to combine uBlock and uMatrix, but I'm not sure I can replicate the functionality I want. Your mention of dynamic filtering is interesting and I wonder if others are using it and can make a recommendation?
I need all JavaScript off by default (including first-party) and the ability to block both ad-serving domains and filters such as /ads/ that work across all domains. Is this possible to do entirely within uBlock Origin?