* You need to make sure you've firewalled (and/or on single-host configurations bound it exclusively to lo0) memcached so people can't talk to it from the Internet.
* If you survey the Internet, you'll find a lot of people who have not obeyed this rule.
* If you don't obey this rule attackers can get and possibly alter most of your data; an exposed memcached is probably game-over for your site.
The only things you should be able to talk to on anything in your data center are ports 443 and 80, plus 25 on your single mail relay if you have one, plus 22 (heavily filtered) on a single relay SSH server. If you can talk to more than that, you've probably done something very wrong.