Great points, thanks @doikor! Will try these.
It would be nice if some of these were the defaults as opposed to some settings folks have to change - say by running a "./configure" or some such.
In this case, for example, it felt a little weird that the machine type which had enough cores had 60GB RAM, and giving only around 10-20GB to Cassandra "felt" wrong, but turns out the exact opposite is true! YugaByte is in C++ and can handle much larger heaps.