If you have a server side application that you hope to be successful then the code will be running all the time and you will pay the price literally because cloud hosting services charge for CPU and RAM usage, which will be off the charts if your server is in Python.
Not to mention all the time you will spend firefighting the performance issues that will inevitably arise. Which also literally costs money in terms of developer salaries and opportunity cost (you can't spend that time to develop new features).