The issues go away if you use a good OpenCL frontend. PyOpenCL for Python goes a long way towards this, and is not really any more awkward than the corresponding PyCUDA, and higher-level languages that generate OpenCL code, like Lift[0] or Futhark[1] (tooting my own horn here), remove the awkwardness completely.
[0]: http://www.lift-project.org/ [1]: https://futhark-lang.org