Pyro (the remote object version) is still around as Pyro4 (and in active development, found here
https://pythonhosted.org/Pyro4/).
We found it great for gradually transitioning from Py2 to Py3
It works nicely in about 95% of use cases with minimal overhead, but there are some gotchas to be aware of (like all strings being serialized as unicode). If we were architecting the whole thing from scratch, some of it might have made more sense with something like gRPC, but it is still a neat tool to have in your toolbox.