I'd be inclined to agree with Adam Michela when he says design systems restrain creativity. It is the industrialization of user interfaces.
As with anything: there is a time and place. Design systems are wildly powerful for scaling, creating a cohesive language across a brand or product, and moving quickly.
Just because you have a design system doesn't mean the buck stops there. You can keep building new roads if you know where it is you need to go that the existing roads won't take you.
1: “Notes on the Synthesis of Form” by Christopher Alexander.