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Comment by masklinn | Hacker News Reader

> An aspirin a day will also make your nose bleed after a few weeks. Albeit not profusely but if you blow your nose, you will see blood.

Should depend on dose and physiology: for low doses (below ~4g) the half life of aspirin is 2 to 4.5h depending on the person. If you saturate the metabolic pathway however the half-life shoots up to 15~30h.

> take one every 3rd say. Unless its a very small dosage with delayed release.

The study was done with 80mg aspirin daily (sometimes called "baby" aspirin). Standard adult dose around here is 500mg.

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The story doesn't end there: aspirin is an irreversible inhibitor of a platelet aggregation pathway.

So its effects last longer than the circulation of free aspirin in the bloodstream.

Its effects last until the enzymes in that pathway get regenerated. The enzymes' turnover is over a period of several days.

A standard dose (tablet) of 250mg and 300mg seem common in Europe, 325mg in the US. 500mg is "extra strength". E.g. https://www.walgreens.com/search/results.jsp?N=2000010035&Nt....

75mg daily here...

[Edit: sorry, mine's clearly not a "standard" dose]

Around where?

It's 300mg in US and UK, for occasional painkiller use. https://en.wikipedia.org/wiki/Aspirin

My experience is with 100mg delayed release over 10 years.

And jesus, 500mg? Holy crap

The "childrens' aspirin" often used by aspirin regimen patients is 81mg (though the general advice is to not give children aspirin due to Reye Syndrome[1]), 500mg daily would cause gastric distress for many people (certainly me).

1: https://en.wikipedia.org/wiki/Reye_syndrome#Aspirin

As far as I know, the over the counter 500mg dose is sold over here as a painkiller, it's certainly not meant for long term preventative use.

> the over the counter 500mg dose is sold over here as a painkiller, it's certainly not meant for long term preventative use.

Most def', but if you ask for aspirin without specifying any further that's what you get (that's what I'm given every time anyway). I'm not sure you can even get 75~80mg, 100mg seems to be the lowest dose available (for long-term use after infarction & stuff, and for toddlers).

In the US and UK one can get ~80mg (75, 81) OTC, at any drug store / chemist.

Sounds pretty damn irresponsible to me.

Im glad my dr is a sane one. I dont see anyone needing high doses unless your dealing with a mayocardial infarction where high doses of aspirin are administired to prevent damage to the heart.

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