Stavros from TileDB, Inc. here: We have elevated the Python/NumPy bindings as our top priority and have already started development. We will try to ship them asap. :)
Also saw in your documentation that you're concentrating on lossless compression right now, which makes complete sense. However, as a scientist, I just want to put a vote in for lossy compression too: it's not uncommon to work with large datasets given in float64 (because float64 is used for any intermediate processing steps), but that actual final precision we need to store is much less than that, but we're stuck with these huge binary files.