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I wonder if there is some universal way to increase DPI for SDL-based apps. I am on linux and I can't read anything =(

SDL2 has SDL_WINDOW_ALLOW_HIGHDPI, which creates the window in high-DPI mode.

Isn't there a way to preprocess the sprites and create 2x and 4x scaled versions?

No, not yet, because of the way data is stored. When we move on to our own save format it will be possible, I'm sure.