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Incendiary bombs used against Germany[0][1] and Japan[2] arguably caused more death and destruction in single air-raids than the singular nuclear attacks on Japan; albeit with a use of greater manpower in the attacks themselves.

How would it compare to modern fission-fusion bombs ?

We're talking orders of magnitude higher yields in modern nuclear weapons compared to the first ones which were roughly comparable to entire air armada's of bombers at the time.

There was a post to HN earlier this year of a site that would estimate damage and allow you to customize the yields, burst-height, prevailing winds, etc. I did not bookmark it as the results are too terrifying.

Found it. http://nuclearsecrecy.com/nukemap/

Not really in one shot. https://en.wikipedia.org/wiki/Father_of_All_Bombs

If you use enough of them, of course.

I meant in one go. And also taking into account modern fusion bombs.