What I see a lot of "power users" doing is simply using their Chromebook to remote into their desktop for their application work. However, what then is the point of putting such powerful hardware in the Chromebook? Either you make a "thin" portable client that is used to remote into your "real" PC, or you make a powerful portable device that is self sufficient.
An overwhelmingly powerful device that can only be used to remote into another system to do the "real" work is simply a waste.