Do you mean scrolling with a mouse? It might sound a bit arrogant, but there's rarely any good reason to scroll with a mouse in vim.
However, with Latex documents, for example, very long lines (i.e., paragraphs) are a big pain for me (even with vimrc options `set display=lastline` and `set linebreak`). In typical GUI text editors, the wrapped lines of long lines are treated as sort of "pseudo lines" themselves. This means when I cursor down (via mouse or keys), the cursor doesn't jump to the next newline after the paragraph (as it does with vim).
Apparently, this last described problem can be addressed [1]. So maybe the solution is that I need to spend more quality time with my vimrc? :)
[1]: http://vim.wikia.com/wiki/Move_cursor_by_display_lines_when_...
In Vim, it'll just do an instant repaint, so you kind of lose context.