Perhaps with a mouse, but not necessarily. I don't think your statement re: mouse scrolling applies universally. For programming script documents, sure -- each line is likely limited to the 80 column mark, and so the lines are quite short.
However, with Latex documents, for example, very long lines (i.e., paragraphs) are a big pain for me (even with vimrc options `set display=lastline` and `set linebreak`). In typical GUI text editors, the wrapped lines of long lines are treated as sort of "pseudo lines" themselves. This means when I cursor down (via mouse or keys), the cursor doesn't jump to the next newline after the paragraph (as it does with vim).
Apparently, this last described problem can be addressed [1]. So maybe the solution is that I need to spend more quality time with my vimrc? :)
[1]: http://vim.wikia.com/wiki/Move_cursor_by_display_lines_when_...