I only played around with it a long time ago. Very interesting language indeed. You may also like Ioke (http://ioke.org/) - a jvm based language that is directly inspired by Io.
Also, fully translatable. Check out Hindi: http://github.com/olabini/ioke/blob/master/examples/multilan...
Here is Ioke's author view on its speed: http://olabini.com/blog/2009/01/iokes-need-for-speed/
I've been looking for a post-lisp for some time now, and while I find Clojure very entertaining, RH took making it a Lisp seriously. This constrains it from the complete and utter evil I can accomplish with Io.