> No current or past history of schizophrenia or other psychotic disorders, no Bipolar I or II disorder, and no first or second-degree (“A second-degree relative is defined as a blood relative which includes the individual’s grandparents, grandchildren, aunts, uncles, nephews, nieces or half-siblings.”) relatives with these disorders.3
https://tripsafe.org/how-to-take-lsd/#1-avoid-with-certain-h...
For what it’s worth:
> “Since the early 1990s, approximately 2000 doses of psilocybin (ranging from low to high doses) have been safely administered to humans in the United States and Europe, in carefully controlled scientific settings, with no reports of any medical or psychiatric serious AEs, including no reported cases of prolonged psychosis or HPPD (Studerus et al., 2011).”1
https://tripsafe.org/shrooms/#2-the-safety-profile-of-shroom...
Psilocybin isn’t the same as ayahuasca or LSD but we’d expect it to have an extremely similar safety and adverse effect profile.