I take Lexapro with Vyvanse. Fantastic combo. The persistently negative thoughts just turned off. I try to take "medication vacations" for tolerance and I can tell by the end of the 1st day the shitty thought patterns come right back in a hurry. It's incredible. The self-loathing and obsessive perfectionism (including having to correct everyone on everything, and not being able to be wrong without getting angry) has nearly completely vanished.