From what I understand, calling WebAssembly functions from JavaScript (and vice-versa) incur a runtime penalty that's way worse than calling JavaScript functions from JavaScript. As such, WebAssembly makes sense for entire applications that would be compiled—think game engines targeting WebGL, or a font rasterizer targeting canvas, etc.
Since this only supports a subset of TypeScript, you won't even be able to compile your dependencies to WebAssembly, meaning that literally any code you interact with that you did not write has this performance setback.