I'm not sure the ease of macro implementation is worth it. I'd love to see more efforts like Dylan. Or different kind of simplicity, like Smalltalk.
But the more code I write, the more I appreciate languages that stay out of my way until I ask for help; besides Lisp & Forth that basically means C/C++. Elaborate syntax, no matter how convenient; will always become an obstacle at some point. You might think it's funny to see C++ in that list, but these days its possible to use it as a static Common Lisp with crippled macros; Snabels implementation is a testament to that.
I was deeply in love with the idea of Smalltalk for a long time, but big pieces of code turn spongy on me as soon as I pass a certain level of complexity. I need more types than that, which is why Snabel had parameterized types from day one.
http://wiki.c2.com/?SweetExpressions
The wiki page makes a valid point; seemingly heavy lisp users will argue against non-s-expression syntax, but happily use prefix notation for quote, and infix for pairs...