Having seen quite a few pitches myself, one good thing you can do is point out your major flaws/obstacles before you're asked about them (assuming they don't clearly spell out your impending demise).
This may seem a little counterintuitive, but it lets you present the issue in a better light and explain how you're going to fix it, instead of having the investor feel like they've discovered a glaring weakness that you were trying to brush under the table. I believe lawyers use a similar technique.
One caveat to this: I'm a blogger/reporter, so investors may have a different perspective. But I'm guessing it holds true for them too.