We ran some casual benchmarks on this at work once, and it's important to note that the performance of AutoLayout dramatically improves based on the degree of nesting you employ.

If you have sixteen views on a cell and their locations all depend upon each other, it's going to take a long time to solve those constraints. But if you can break up the cell, say into four subviews with four elements inside them, it's likely to be faster (no guarantees, though)