Although I don't necessarily agree with all the points in this article, it just reminds me what Poincaré said:
`You ask me to predict for you the phenomena about to happen. If, unluckily, I knew the laws of these phenomena I could make the prediction only by inextricable calculations and would have to renounce attempting to answer you; but as I have the good fortune not to know them, I will answer you at once. And what is most surprising, my answer will be right.' -- Poincaré, H. (1913) The Foundations of Science. New York, The Science Press. p. 396.
That said, quant researchers typically understand how the market works. They are just able to quickly excel without a background in it.
You're used to see the techniques you work with capture signal because there isn't an army of PhDs in math, physics, and computer science working around the clock to trade any signal out of that data.
In the end, it doesn't even matter if you're the best statistician in the world: whatever signal you detect may simply not be worth the effort you put into detecting it.