That said, this is very much not for me. Default-colorized is something I emphatically do not want; defaulting to relative units, ditto. It it were me, the first thing I would do is get rid of 'grid' display entirely - reading across just doesn't work for me. Etc.
More prosaically, `ls` is sort of like breathing for me - I do it so much during the average day that I don't even think about it. Can't say I immediately know every one of the switches, but probably 10 or so variants I use daily are pure muscle memory, and less frequently used things (extended attributes, symlink-deref options, etc.) I can remember without the man page.
So in that sense, `ls` is well into the same category as vi for me - I'm so accustomed to whatever warts there may be that switching would be much more painful than any efficiency gain.