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I tried it but it didn't work for me. I'm running Mavericks. Do I need to reboot or something?

I've only tested on Sierra, so I'm not terribly surprised that this doesn't work. Would you mind opening an issue so I can help debug? https://github.com/github/SoftU2F/issues/new

Done.

Are you triggering U2F challenges by visiting sites that support u2f? Opening the app doesn't do anything.

Yes. The configuration I was using (Yubico test site on Chrome) works against hardware tokens.

Just for context, I'm pretty well versed in U2F. I actually sell a U2F token of my own (https://sc4.us/hsm) and I've published a serverless U2F test harness (https://github.com/rongarret/u2f-test).

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