It goes without saying that ludicrous regulations like "historically protected" homes that you can't remodel without bribing the city and trees on your property that you don't own (the city owns) that exist in SF don't exist in Pittsburgh.
On another note, the nice thing about Pittsburgh is that you don't have such an oppressively high cost of living compared to SF. You don't have $10 toast here, and you can rent a 1 bdr apartment for the cost of renting a single parking spot for your car in SF. Every single cost from utilities to parking to insurance for your car is a significant fraction of the equivalent cost in SF.
Also, I imagine the winters there can be harsh.
Is it the lack of proper bike lanes on the bridges?