I've been working from home for a number of years. During this time I've on average spoken with and interacted with 1 person every day - my wife.
I occasionally go out, occasionally see family members, but the majority of my day-to-day work is quiet, alone, working at a computer.
- I have been more sick in recent years than ever before in my life. This is even compared to previously living in a major city and taking public transportation.
- I have been experiencing sharp mental decline especially in the last year. Solving complex problems is much more challenging.
- My memory is suffering. Even my wife has begun to notice, I forget little things and have developed an "aloof professor" disposition that wasn't natural to me.
- I now find social interaction more difficult. I'm more akward, and find myself over-thinking previously natural interactions.
- Lastly ... I'm far more depressed. I just don't enjoy much these days. I wake up, work, don't talk to many people.
The TLDR here is that I urge everyone to tend to their social garden. I let mine decay for too long, and I'm paying the price now. I am beginning the process of restoring connections, and getting out more, and I'm already noticing an improved mood.
Oh and I should mention - I'm naturally an introvert so this reclusive lifestyle was all too comfortable for me.