Though I am a happy user too, we are worried about a huge Black Swan scenario.
That said, things will run just fine, even with downtime, if you're not depending on the machine in any way, don't have any local storage, and are capable of switching over to other systems. However the lack of downtime might lull people into not worrying about that stuff.
I will be surprised if Amazon doesn't work out the reliability issues anyway, given the massive resources and smart people it has available to it.