I have 4 boys all healthy and a decent career. It's gone well for me, but there were scary parts...it increased the personal stress a lot in times like when my start-up/s failed.
It never hampered my ambition though. My wife and I are a team. We've spent 6 months plus apart as I pursued start-ups in Texas and during YC. I've never looked at my family as holding me back in any way.