From a protocol level, NVMe is actually designed for SSDs - just look at the amount of queues it has https://en.wikipedia.org/wiki/NVM_Express#cite_ref-ahci-nvme.... To really take advantage of this, you'd need your filesystem to be designed for many independent IO streams. ZFS metaslabs probably help, but I'm sure there is more you can do in this area.

On the other hand, I don't think many people would be hitting any limits where this matters.