I feel like I'm one of a huge crowd and being ignored completely is very common, even when I surpass all of their requirement check-boxes boxes, then some.
I spend a good amount of time on each cover letter, research the company, and email the CEO or a lead developer on the team. I very rarely get a response, but twice I got to the first stage and then it's as if I was forgotten.
I'm currently employed in a non-remote position, and I would be able to get a new local job with ease simply because I can walk in and talk to someone. I have gotten offers already, but I have a good list of reasons for wanting a remote position.
I'm persisting, but it's getting a bit tiring going this long at it.