The Brain Bag by itself is not well organized, but add a Brain Cell to hold the laptop, a Snake Charmer for cables, and a Freudian Slip for papers and you're getting somewhere. You're also getting spendy, so there is that. But the bags last forever and show great attention to detail in their construction. (Another risk is that you'll soon find yourself buying a Bihn travel bag, briefcase, etc...)

The eBags Professional Weekender looks interesting.

I was also looking at an Osprey: https://www.amazon.com/Osprey-Porter-Travel-Backpack-46-Lite...