For me it's just a matter of what you're used to. We're used to 2+2, and sin(x) so that's what we do. If you learned +(2,2) then that's what's more intuitive for you. And with time you get used to new approaches anyway.

Also, infix has the unfortunate problem of requiring operator priorities to parse.

    f(2, g(3, 4))

is impossible to misunderstand.

    2 f 3 g 4

isn't.