I have some fond memories of hacking around with it, about 10 years ago - although for some context, I was coming out of the wastelands of Visual Basic, pre-modern C++, and AWT/Swing era Java. I'm not sure there's anything easier for quick and dirty 2D game development than the PyGame SDL bindings were.
But I'd cringe at the thought of building anything serious with it today. It feels too loose and sloppy, like trying to build a castle made of sand, although I might have some Stockholm syndrome from years of more static, more strongly typed languages. But I have to do enough grepping around through the code base now to make sure tweaking something isn't going to break some snippet of JS code on the front-end now; I really don't need to be worried about that on the back-end too.