It's a very deep thought, if you go past the literal interpretation.
EDIT:
Before you down vote, read what I meant, since it is obvious that if you are considering a down vote then you're not getting what I'm referring to, and probably think I'm talking about numerology.
What I'm referring to is his choice of a number to represent the answer to life, universe and everything. Not a magical number, but just A NUMBER. It shows how futile it is to try and answer some questions in a mechanical/mathematical way. Some questions are not computable, and there is more meaning to life beyond the rational.