NoScript definitely works without XUL support and is the fourth most popular extension listed on the compatibility page here: https://www.arewee10syet.com/
Tested and working, for a while now.
e10s is multi-process, I thought, which is a different animal to the new plug-in framework they are pushing. I'm pretty sure I read no-script will have problems, but that might have been with regards to tree style tabs instead (which is shown to work in the multi process branch)