Dunno how well it will work after Mozilla drops support for XUL extensions...
NoScript definitely works without XUL support and is the fourth most popular extension listed on the compatibility page here: https://www.arewee10syet.com/
Tested and working, for a while now.
e10s is multi-process, I thought, which is a different animal to the new plug-in framework they are pushing. I'm pretty sure I read no-script will have problems, but that might have been with regards to tree style tabs instead (which is shown to work in the multi process branch)