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Comment by threepipeproblm | Hacker News Reader

I don't know if they specifically apply to this study, but Stephan Guyenet has pointed out some of the potential problems with what are typically called "high-fat" diets for mice.*

For example one research diet that is called high-fat, D12492 - is extremely high in fat (60%) - does not contain what are generally considered to be particularly healthy forms of fat - is extremely processed overall - is typically used with genetically obesogenic mice - typically causes obsesity and neuron damage (and often diabetes) at a young age.

I would think there are quite a few studies on Intermittent Fasting (IF) that more easily generalize to humans.

* http://wholehealthsource.blogspot.com/2012/01/high-fat-diets...

ADDENDUM: Here is the diet used in the actual study. http://www.labdiet.com/cs/groups/lolweb/@labdiet/documents/w... Some of the top ingredients are soy products (which in high enough doses will render most animal species infertile).

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Some of the top ingredients are soy products (which in high enough doses will render most animal species infertile)

Can you show legitimate repeatable recent research that shows this. I'm starting to think that the Soy raising estrogen (to unhealthy levels) thing may not be as true and is perpetuated in some cases as broscience.

I'm sorry, the research I reviewed on animal infertility was a long time ago. The studies that were from the first half of the 20th century in which this result was demonstrated on just about every domestic farmed species. I don't have time at the moment to track those down. But I don't believe this is 'broscience'.

The first place I'd look if you're searching for studies, esp. more modern ones, is actually the Weston A. Price Foundation. While they have an agenda for sure (e.g. they are currently suing the US prison system for malnourishing inmates, just to name one example of activism/ideology) I think they are generally good folks. They have sponsored some top-notch researchers, such as Chris Masterjohn, in the past.

Here is their scary soy page, which starts with a few citations. I think you'd find more in some of the linked articles.

https://www.westonaprice.org/soy-alert/

Price was a fascinating bro, BTW.

Please feel free to post here anything that you may find to be of particular interest.

I should add that most of these results probably don't apply to traditionally fermented soy (like natto or traditionally made soy sauce -- but not the mass produced stuff nowadays); as I understand it there is no traditional culture which ate soy in an unfermented form.)

Thanks. I'm always trying to reduce meat and other animal product consumption but its fairly difficult with out some if not a large portion of soy consumption.

I'll have to check if tempeh (which is what I normally eat) has the same soy dangers (it is supposedly traditional fermented).

Another way to reduce meat and animal product consumption, though counter intuitive, may be bone broth / anything with gelatin or glycine. I understand it has a "protein sparing" effect, meaning you can eat less protein total without muscle wasting. Our ancestors got a higher ratio of this stuff by eating more of the whole animal, rather than eating primarily muscle muscle bellies, as we tend to do today.

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