Specifically: bitcoin depends on distributed mining power in order to prevent individual miners from being able to manipulate the blockchain.
However, if you accept that (1) there are economies of scale in mining, and (2) miners are rational and will only mine when they can make a profit, then I see no reason to believe mining power should stay "distributed" rather than develop into a monopoly.
I realize this hasn't happened yet, but I don't think it makes sense to base a currency on such shaky foundations.
The basic argument is also made in the paper discussed here:
https://www.cryptocoinsnews.com/declining-profitability-for-...
also: