What I want to know is: Is there some kind of mode of attack we can use, such that when the bacteria develop a resistance to it, in order to have the resistance they must necessarily become vulnerable to something else.

If you have two or three of these things which are mutually linked. The bacteria can become resistant to one but will become vulnerable to the other.

I am however not a biologist, just a developer, so please excuse me if I am mistaken.

Is such a thing even possible? Is some one working on something like this?