Startups do not have the same level of people experiences to draw conclusions based on interviewing thousands and thousands of applicants and tracking the success of accepted applicants based on a large portfolio of information.
Probably the best thing you can do in a situation like this is GET someone from a company like that who has had years of experience interviewing candidates, and they will be able to bring along that experience of identifying potential false positives from the get go. That is honestly the biggest asset to these companies, their ability to hire and maintain high quality people.
in addition to the countless benefits and opportunities for varied career trajectories in multiple and evolving technologies for smart people once getting into these places, is the fact that they highly value the social network of these work places, and they cannot be duplicated in many places elsewhere, further incentivizing them to stay and internally recommending other high quality friends from elsewhere to interview.