I've only ever done web. What's the difference in your opinion?
Even now, there isn't any Web tool that allows for designing Web UIs like Microsoft Blend (XAML) or Qt Creator (QML).
The Web could have been like that if XHTML and its related standards were adopted, then we could have had something like XUL or XAML.
Instead we have the broken promise of Web Components that still aren't properly supported across all major browsers, or the "UI framework of the day" without any kind of tooling support besides code.